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Asthma

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Posted by on Monday, September 20, 2010, 6:15
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Asthma is a chronic respiratory disease-sometimes worrisome and inconvenient-but a manageable condition. It is also known as reactive airway disease. With proper understanding, good medical care and monitoring, you can keep asthma under control.

Asthma
Asthma

If you have asthma, you are not alone. In the United States, asthma affects 14 to 15 million people. Asthma, also known as reactive airway disease, is defined as a chronic lung condition with inflammation (swelling) of the airways, increased sensitivity of the airways to a variety of things that make asthma worse, and obstruction of airflow that is reversible.

There are various type of asthma, including:

* Exercise-induced asthma
* Nocturnal asthma
* Occupational asthma
* Steroid resistant asthma
* Allergic asthma

Typical Changes in the Airway
Inflamed airways

Inflammation
Recent research has shown that inflammation of the lining of the airways is the most common feature of asthma. When they are stimulated, certain cells lining the airways release chemical substances (mediators) that lead to inflammation. This causes the airway lining to swell and narrow. The inflammation may last for hours, days or weeks following an episode. Most people with asthma have some degree of inflammation all of the time. Some long-term control medications can help prevent and reduce inflammation.

Increased Sensitivity
Another characteristic of asthma is increased sensitivity of the airways. When inflammation occurs in the airways, the airways become more sensitive (or “twitchy”). When the airways are more sensitive, you are more likely to have asthma symptoms when exposed to things that can make asthma worse. The more sensitive your airways, the less it takes to cause a problem. When there is less inflammation, the airways are less sensitive and you are less likely to have asthma symptoms when exposed to things that make asthma worse.

Airway with Inflammation, Bronchospasm and Mucus Production Airway Obstruction
In addition to the swelling that occurs as a result of inflammation, further airway obstruction sometimes occurs with asthma. Obstruction is caused by tightening of muscles that surround the airways. This is also called bronchospasm. Bronchospasm causes further narrowing of the inflamed airways. Inhaled quick-relief medications are generally very effective in reversing bronchospasm.

In most people with asthma, the mucus glands in the airways produce excessive, thick mucus, which further obstructs the airways and causes coughing.

Treatment of Asthma Treatment:

Asthma cannot be cured, but it can be controlled with proper asthma management.

The first step in asthma management is environmental control. Asthmatics cannot escape the environment, but through some changes, they can control its impact on their health.

Listed below are some ways to change the environment in order to lessen the chance of an asthma attack:

* Clean the house at least once a week and wear a mask while doing it

* Avoid pets with fur or feathers

* Wash the bedding (sheets, pillow cases, mattress pads) weekly in hot water

* Encase the mattress, pillows and box springs in dust-proof covers

* Replace bedding made of down, kapok or foam rubber with synthetic materials

* Consider replacing upholstered furniture with leather or vinyl

* Consider replacing carpeting with hardwood floors or tile

* Use the air conditioner

* Keep the humidity in the house low

The second step is to monitor lung function. Asthmatics use a peak flow meter to gauge their lung function. Lung function decreases before symptoms of an asthma attack – usually about two to three days prior. If the meter indicates the peak flow is down by 20 percent or more from your usual best effort, an asthma attack is on its way.

The third step in managing asthma involves the use of medications. There are two major groups of medications used in controlling asthma – anti-inflammatories (corticosteroids) and bronchodilators.

Anti-inflammatories reduce the number of inflammatory cells in the airways and prevent blood vessels from leaking fluid into the airway tissues. By reducing inflammation, they reduce the spontaneous spasm of the airway muscle. Anti-inflammatories are used as a preventive measure to lessen the risk of acute asthma attacks. The corticosteroids are given in two ways – inhaled via a metered dose inhaler (MDI) or orally via pill/tablet or liquid form. The inhaled corticosteroids are flunisolide (AeroBid), triamcinolone (Azmacort) and beclomethasone (Beclovent and Vaceril). The oral corticosteroids (pill/tablet form) are prednisone (Deltasone, Meticorten or Paracort), methylprednisolone (Medrol) and prednisolone (Delta Cortef and Sterane). The oral corticosteroids (liquid form) are Pedipred and Prelone. These liquid forms are used for asthmatic children.

Three drugs, zafirlukast (Accolate), montelukast (Singulair) and zileuton (Zyflo), are part of a newer class of anti-inflammatories called leukotriene modifiers. Taken orally, these drugs work by inhibiting leukotrienes (fatty acids that mediate inflammation) from binding to smooth muscle cells lining the airways. They also reduce the recruitment of inflammatory cells to the airways. These drugs both prevent and reduce symptoms, and are intended for long-term use.

Other inhaled anti-inflammatory drugs include cromolyn sodium (Intal) and nedrocromil (Tilade).

Bronchodilators work by increasing the diameter of the air passages and easing the flow of gases to and from the lungs. They come in two basic forms – short-acting and long-acting. The short-acting bronchodilators are metaproterenol (Alupent, Metaprel), ephedrine, terbutaline (Brethaire) and albuterol (Proventil, Ventolin). These drugs are inhaled and are used to relieve symptoms during acute asthma attacks. The long-acting bronchodilators are salmeterol (Serevent), metaproterenol (Alupent), and theophylline (Aerolate, Bronkodyl, Slo-phyllin, and Theo-Dur to name a few). Serevent and Alupent are inhaled and theophylline is taken orally. These drugs are sometimes used to control symptoms in special circumstances, such as during sleep or when intensive exposure to a particular irritant can be predicted (i.e. pollen season). Atrophine sulfate (Atrovent) is another highly effective bronchodilator. This drug opens the airways by blocking reflexes through nerves that control the bronchial muscles.

Some people cannot control the symptoms by avoiding the triggers or using medication. For these people, immunotherapy (allergy shots) may help. Immunotherapy involves the injection of allergen extracts to “desensitize” the person. The treatment begins with injections of a solution of allergen given one to five times a week, with the strength gradually increasing.

Note: Asthmatics vary considerably in their responses to different types, combinations and amounts of medicines so therapy must be carefully tailored to the individual. Even medication that may work well with some asthmatics may not be effective for others. Please discuss your individual situation with your doctor and both of you will determine a course of management that is best for you.

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